Insulin resistance and heart diseases: is there a relationship?
We consider the nature of insulin resistance (IR) underlying on development of type 2 diabetes mellitus and metabolic syndrome, and the main cellular and molecular mechanisms of its formation are presented. The paper is dedicated to the pathogenetic link between IR and hypertension, IR importance in the development of diabetic cardiomyopathy. It is emphasized that metformin (Siofor) is the best drug for insulin sensitivity restoration and improvement of prognosis in cardiac patients. The presence of a various cardioprotective effects of metformin facilitates therapy optimization for patients with high risk of cardiovascular disease.

Keywords: type 2 diabetes mellitus, metformin, insulin resistance, metabolic syndrome, cardiovascular disease