Nifuratel-based Helicobacter Pylori Eradication Scheme In Children And Adults: Evaluation Of Efficacy With The Help Of Hp-antigen Method

S.Yu. Konanychina, O.A. Serduk, I.I. Stepanova, M.L. Kastorina

Nifuratel-based Helicobacter pylori eradication scheme in children and adults: evaluation of efficacy with the help of Hp-antigen method
We presents the results of study on the efficacy and safety of tricomponent therapy with omeprazole, amoxicillin and nifuratel use based on the results of HP-antigen identification in coprofiltrates, which included 32 children and 35 adults with chronic inflammatory diseases of the upper gastrointestinal tract, associated with Helicobacter pylori (HP). Therapy-induced clinical symptoms improvement and erosive and ulcerative mucosal defects epithelization were noted in all patients. Eradication was achieved in 93.8% of children and 88.6% of adults based on the results of histological examination of biopsy samples and immunochromatographic analysis of fecal specimen. Treatment regimen was well torelated, side effects such as nausea and unformed stool was registered only in 6.3% of children and 8.6% of adults. Thus, the nifuratel-based scheme in combination with omeprazole and amoxicillin is effective and safe for the eradication of HP infection in children and adults. Noninvasive immunochromatographic short-term test based on monoclonal antibodies for the HP-antigens identification in fecal specimen can be used for the diagnosis of HP infection and assessment the efficacy of the therapy.

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