Influence of renin-angiotensin-aldosterone system blockade on atrial fibrillation course
Despite the great success in understanding of many electrophysiological mechanisms of atrial fibrillation (AF) developing and maintaining, until know there is no universal method of its treatment. Using of antiarrhythmic drugs for sinus rhythm maintaining is limited by its low effectiveness. It is reasonable to suppose that the blockage of renin-angiotensin-aldosterone system can decrease the number of the first episodes of AF and prevent the relapses. The article includes the results of the studies evaluating the effects of inhibitors of angiotensin-converting enzyme and angiotensin II receptors blockers on the development and progress of AF. These drugs can prevent AF and its complications, probably by means of regress of structural and functional remodeling of myocardium.

Keywords: angiotensin II receptors blockers, inhibitors of angiotensin-converting enzyme, renin-angiotensin-aldosterone system, atrial fibrillation