Atrial fibrillation (AF) is the most common heart rhythm disorder requiring treatment, the prevalence of which increases with age. Pharmacological drugs are the first-line therapy for AF treatment. Antiarrhythmic drugs (AADs) are used as emergency therapy to terminate recently developed AF and to maintain sinus rhythm as a planned therapy to prevent recurrence of arrhythmia. The review presents data on the most commonly used AAD in clinical practice for the treatment of AF, propafenone. A distinctive feature of propafenone is the possibility of its use at all stages of medical care: outpatient, emergency, inpatient, both orally and intravenously. The drug can be used both to interrupt paroxysmal AF and to maintain sinus rhythm in planned therapy.

Keywords: prevention of atrial fibrillation recurrences, propafenone, paroxysmal atrial fibrillation, antiarrhythmic drugs, atrial fibrillation