Simvastatin in the treatment of atherosclerosis
Statins (inhibitors of HMG-CoA reductase) are the class of lipid-lowering drugs with a large amount of evidence-based data, confirming its efficiency on lipid lowering and decreasing of cardiovascular and total mortality. Statins can slow the progression of atherosclerosis, decrease coronary and periphery atherosclerosis, and also have anti-ischemic, anti-inflammatory, antithrombotic and other effects. Now simvastatin is one of the most frequently used statins. This review summarizes data on its clinical efficiency in atherosclerosis treatment.

Keywords: lipid-lowering therapy, simvastatin, statins, atherosclerosis, cholesterol