Pantoprazole use in the treatment of symptomatic (stress) gastro-duodenal ulcerations
Stress ulcers (SU) - symptomatic gastroduodenal erosions with stomach predominance. They arise due to extensive surgical interventions on the abdominal cavity organs and aorta, and myocardial infarction. The main pathogenetic mechanisms of SU are: ischemia of gastric and duodenum mucosa, hypovolemia, hypotension and apoplasmia; increase of ACTH, corticosteroids, catecholamines, and histamine production, which has an adverse effect on the mucous membrane, and enhancing the acid-peptic factor; gastroduodenal motility disturbanses (gastroparesis and enteroparesis, duodenogastric reflux). In modern therapy of SU, proton pump inhibitors with minimal potential for drug interactions having a dosage form for parenteral and oral administration are often used. SU management with pantoprazole, its efficacy for standard doses administration in comparison with other proton pump inhibitors are presented.

Keywords: gastrointestinal bleeding, pantoprazole, stress ulcers, proton pump inhibitors