Modern principles of diagnosis and treatment of GERD. What is the place of alginates?


DOI: https://dx.doi.org/10.18565/pharmateca.2022.2.56-62

M.V. Chebotareva (1, 2), K.A. Nikolskaya (1, 2), E.R. Valitova (1), D.S. Bordin (1, 3, 4)

1) A.S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow Healthcare Department, Moscow, Russia; 2) Research Institute of Health Organization and Medical Management of the Moscow Healthcare Department, Moscow, Russia; 3) Tver State Medical University, Tver, Russia; 4) A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Gastroesophageal reflux disease (GERD) is one of the common diseases with increasing incidence. Diagnosis is based on clinical evaluation of symptoms and response to antireflux therapy; detection of damage to the mucous membrane of the esophagus during endoscopy and pathological changes according to reflux monitoring. In recent years, the criteria for making a diagnosis have been revised and become more stringent. Proton pump inhibitors are recommended as the most effective class of drugs for the treatment of GERD. At the same time, the issue of prescribing drugs that can quickly stop the symptoms of the disease, improve the effectiveness of therapy and the quality of life of patients remains relevant. The accumulated scientific data and long-term experience of use allows to consider alginates, drugs with a physical antireflux mechanism of action, not only as an rescue medications for heartburn and for long¬term monotherapy or in combination with PPIs, but also to take into account their effectiveness as a diagnostic criterion for the disease. A review of key consensus documents on the diagnosis and treatment of GERD is presented.

About the Autors


Corresponding author: Dmitry S. Bordin, Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases and Gastroenterology, A.I. Yevdokimov Moscow State Medical University; Head of the Department of Pathology of the Pancreas, Biliary Tract and Upper Digestive Tract, A.S. Loginov Moscow Clinical Scientific and Practical Center ofthe Moscow Healthcare Department (Moscow), Professor, Department of Outpatient Therapy and Family Medicine, FPGE, Tver State Medical University, Tver, Russia; d.bordin@mknc.ru


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