Constipation is a serious medical and social problem due to the widespread prevalence of this condition, decreased quality of life and social activity of patients. Functional constipation is a common gastroenterological pathology with no physiological, anatomical or iatrogenic origin can be identified.
The possibilities of natural mineral waters rich in magnesium sulfate in the treatment of constipation are considered. To date, three magnesium sulfate-rich natural mineral waters have been studied in randomized, double-blind, placebo-controlled clinical trials.
A comparison of the effectiveness of the three mineral waters studied showed that Donat mineral water is the most effective. The results of a randomized clinical trial of Donat mineral water in the treatment of functional constipation, as well as the experience of its use in domestic studies that demonstrated the effectiveness and safety of Donat medicinal mineral water in pediatric practice and in adult patients with functional constipation are discussed in detail.
The characteristics of natural mineral water Donat allow to consider it as the first choice for the treatment of constipation in certain categories of comorbid patients. The rationale for the use of Donat mineral water for the treatment of constipation in patients with concomitant periodontal diseases and for the treatment of drug-induced constipation caused by the use of proton pump inhibitors is presented.

Keywords: periodontal disease, Donat Mg, medicinal mineral water, Donat, sulfate, drug-induced constipation, functional constipation, proton pump inhibitors, magnesium, calcium, treatment