Modern mucoactive therapy. Clinical aspects of erdosteine use


DOI: https://dx.doi.org/10.18565/pharmateca.2025.1.181-187

I.V. Leshchenko, N.A. Esaulova, E.A. Medvedsky

1) Ural State Medical University, Yekaterinburg, Russia; 2) Ural Research Institute of Phthisiopulmonology – Branch Campus of the National Medical Research Center for Phthisiopulmonology and Infectious Diseases, Yekaterinburg, Russia; 3) Medical Association “New Hospital” LLC, Yekaterinburg, Russia
Erdosteine is a prodrug, the main indication for use of which is the treatment of acute and chronic lung diseases accompanied by the formation of difficult-to-separate viscous sputum. Today, there is a large evidence base in the literature devoted to the various effects of erdosteine. The presented studies demonstrate the unique properties of erdosteine and confirm that the indication for its use are acute and chronic respiratory diseases with the production of viscous, difficult-to-separate sputum. Additional, but no less important effects of erdosteine, such as antioxidant, anti-inflammatory, antibacterial activity, position it as a drug necessary for the treatment of exacerbations of chronic respiratory diseases. Erdosteine increases the effectiveness of bronchodilators, antibacterial therapy, reduces the frequency and duration of exacerbations of chronic obstructive pulmonary disease and chronic bronchitis, prolongs the time between exacerbations, reduces their risk.
Keywords: productive cough, erdosteine, mucoactive therapy
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About the Autors

Igor V. Leshchenko, Dr. Sci. (Med.), Professor, Department of Phthisiology and Pulmonology, Ural State Medical University; Chief Researcher,
Ural Research Institute of Phthisiopulmonology – Branch Campus of the National Medical Research Center for Phthisiopulmonology and Infectious Diseases; Scientific Director of the clinic of the Medical Association “New Hospital”, Yekaterinburg, Russia; leshchenkoiv@yandex.ru, ORCID:
https://orcid.org/0000-0002-1620-7159; eLibrary SPIN: 1851-8986 (corresponding author)
Natalia A. Esaulova, Cand. Sci. (Med.), Head of the Department of Differential Diagnostics, Ural Research Institute of Phthisiopulmonology – Branch Campus of the National Medical Research Center for Phthisiopulmonology and Infectious Diseases, Yekaterinburg, Russia; esanat1@yandex.ru, ORCID: https://orcid.org/0000-0001-9565-3570
Evgeny A. Medvedsky, Cand. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Medicine of the Institute of Pediatrics and Reproductive Medicine, Ural State Medical University, Yekaterinburg, Russia


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