Background. With increasing life expectancy in the population, vascular cognitive impairment (CI) is becoming one of the most important health problems.
Objective. Evaluation of the effectiveness of meldonium in patients with mild CI after lacunar stroke.
Methods. The open comparative study included 38 patients aged 45 to 55 years with mild CI diagnosed in the acute period of lacunar stroke. Diagnosis of mild CI was carried out on the basis of clinical and psychological examinations using the Arnold-Kohlman test in three parameters: abstract thinking, practical thinking, memory. Nineteen patients (the main group) were prescribed meldonium at a dose of 1000 mg intravenously for 20 days against the background of basic therapy, 19 patients (the comparison group) received basic therapy.
Results. Assessment of cognitive functions using the Arnold-Kohlman test revealed a statistically significant improvement in the performance of subtests for abstract thinking and memory in patients receiving meldonium.
Conclusion. The results of the treatment showed that the use of meldonium in patients with mild CI in the acute period of lacunar stroke is effective.

Keywords: mild cognitive impairment, meldonium, lacunar stroke