ENERGY METABOLISM CORRECTOR MILDRONATE®: INTERRELATION OF MECHANISMS OF ACTION AND THERAPEUTIC EFFECTS


V.Ya. Dzerve

Institute of Cardiology and Regenerative Medicine of the University of Latvia
The article clarifies the mechanisms of action of meldonium (Mildronate®). It is emphasized that the evaluation of these mechanisms can significantly expand the range of application of the drug. In particular, article states that metabolic cytoprotection caused by Mildronate® is one of the promising directions in the treatment of chronic ischemia of the lower extremities, and the improvement of endothelial function against the background of use of this drug is an important pathogenetic link in improving the functional capacity of such patients. The prospects of use of Mildronate® in diabetes mellitus and such severe complications of this disease as diabetic neuropathy and nephropathy are discussed.

About the Autors


Corresponding author: V.Ya. Dzerve – Institute of Cardiology and Regenerative Medicine of the University of Latvia


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