Neuropeptide Substance P (SP) is an important peptide produced by the central and peripheral nervous systems, as well as immune cells, with a wide range of biological activity.
Objective. Summarizing the available data on the role of SP in the mechanisms of development and treatment of skin inflammatory processes. The analysis of foreign sources in the PubMed/Medline databases and domestic sources in the scientific electronic library Elibrary was carried out.
An increase in the SP level was noted in a number of skin diseases, such as atopic dermatitis (AD), urticaria, pruritus. SP plays an important role in the mechanisms of development and maintenance of neurogenic inflammation. One of the new directions in medicine is the use of exogenous SP as a treatment for skin inflammatory processes. SP causes an acute inflammatory reaction in the wound and improves the processes of skin cell regeneration.
SP is a very important and significant neuropeptide that takes part in the development and maintenance of a number of pathological conditions. The versatility of the biological role of SP determines the clinical picture of diseases. The area of application of SP as a treatment for skin inflammatory processes is relatively new and little studied.

Keywords: chronic wounds, neurogenic inflammation, substance P, treatment