The article presents data on rosacea, a chronic relapsing inflammatory skin disease with a high prevalence among fair-skinned adults of Northern European origin. It is known that various environmental factors, endogenous factors stimulate an enhanced innate immune response and neurovascular dysregulation, while the etiopathogenesis of rosacea requires further study. The article discusses trigger factors for rosacea, including endoplasmic reticulum stress and an extended protein response; ultraviolet radiation and thermal, mechanical, nutritional, psychological and other adverse risk factors. Information on the relationship of concomitant cardiovascular, neurological diseases in rosacea is also provided.

Keywords: rosacea, comorbidities, trigger factors