Русский
The effect of pregnancy and thyroid hormones on the occurrence and course of extrasystole
DOI: https://dx.doi.org/10.18565/pharmateca.2023.4-5.72-78
O.P. Vinogradova, F.K. Rakhmatullov, M.A. Ostanin, R.F. Rakhmatullov
1) Penza Institute for Postgraduate Medical Education – Branch Campus of RMACPE, Penza, Russia; 2) Medical Institute, Penza State University, Penza, Russia
Background. The study of the effect of pregnancy hormones on the occurrence and course of extrasystolic arrhythmia is one of the most difficult issues in modern medicine.
Objective. Evaluation of the effect of chorionic gonadotropin, progesterone, thyroid hormones and type 1 diastolic dysfunction on the occurrence and course of ventricular extrasystole in pregnant women.
Methods. 32 pregnant women with ventricular extrasystole (Group 1) and 30 pregnant women without extrasystole (Group 2) without heart pathology, aged 19–38 years (mean age 29.8±2.4 years) were examined. Research methods included general clinical studies, electrocardiogram (ECG), echocardiography (EchoCG), 24-hour ECG monitoring, determination of the levels of chorionic gonadotropin, progesterone, and thyroid hormones.
Results. A close relationship (p<0.05) between chorionic gonadotropin and thyroid-stimulating hormone levels and extrasystole was revealed. A regression model predicting the course of extrasystolic arrhythmia in pregnant women with AF was constructed. It was found that the predictive value of the equation is 98.6%. The antiarrhythmic effect of the combined use of potassium preparations with magnesium was established.
Objective. Evaluation of the effect of chorionic gonadotropin, progesterone, thyroid hormones and type 1 diastolic dysfunction on the occurrence and course of ventricular extrasystole in pregnant women.
Methods. 32 pregnant women with ventricular extrasystole (Group 1) and 30 pregnant women without extrasystole (Group 2) without heart pathology, aged 19–38 years (mean age 29.8±2.4 years) were examined. Research methods included general clinical studies, electrocardiogram (ECG), echocardiography (EchoCG), 24-hour ECG monitoring, determination of the levels of chorionic gonadotropin, progesterone, and thyroid hormones.
Results. A close relationship (p<0.05) between chorionic gonadotropin and thyroid-stimulating hormone levels and extrasystole was revealed. A regression model predicting the course of extrasystolic arrhythmia in pregnant women with AF was constructed. It was found that the predictive value of the equation is 98.6%. The antiarrhythmic effect of the combined use of potassium preparations with magnesium was established.
About the Autors
Corresponding author: Fagim K. Rakhmatullov, Dr.Sci. (Med.), Professor, Department of Internal Medicine, Medical Institute, Penza State University, Penza, Russia; pgu-vb2004@mail.ru
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