Русский
Features of the cytokine status, lipid peroxidation and the state of the antioxidant system in patients with true eczema
DOI: https://dx.doi.org/10.18565/pharmateca.2022.14.73-77
L.A. Novikova, E.V. Dontsova, A.V. Chernov, O.S. Saurina, V.G. Dontsov, T.I. Pogodaeva
Voronezh State Medical University n.a. N.N. Burdenko, Voronezh, Russia
Objective. Evaluation of the features of the blood cytokine status, oxidative processes and the state of the antioxidant system in patients with true eczema in the acute stage.
Methods. The study included 131 patients (mean age 58.7±3.6 years). Serum levels of pro-inflammatory cytokines – interleukins (IL) IL-1β, -2, -6, IFN-γ, TNF-α and anti-inflammatory cytokine IL-10, as well as indicators characterizing the state of oxidative stress and antioxidant protection were determined by enzyme immunoassay.
Results. It has been established that during exacerbation of true eczema in patients, increased production of a complex of pro-inflam- matory ILs, as well as IFN-γ and TNF-α, was detected, accompanied by a decrease in the anti-inflammatory IL-10 level. Along with this, activation of the processes of lipid peroxidation (LPO) and insufficient production of the components of the antioxidant system were noted.
Conclusion. Direct correlation between the activity of the system of pro-inflammatory cytokines and the severity of LPO processes was
established; it must be taken into account when planning a complex of therapeutic measures.
Methods. The study included 131 patients (mean age 58.7±3.6 years). Serum levels of pro-inflammatory cytokines – interleukins (IL) IL-1β, -2, -6, IFN-γ, TNF-α and anti-inflammatory cytokine IL-10, as well as indicators characterizing the state of oxidative stress and antioxidant protection were determined by enzyme immunoassay.
Results. It has been established that during exacerbation of true eczema in patients, increased production of a complex of pro-inflam- matory ILs, as well as IFN-γ and TNF-α, was detected, accompanied by a decrease in the anti-inflammatory IL-10 level. Along with this, activation of the processes of lipid peroxidation (LPO) and insufficient production of the components of the antioxidant system were noted.
Conclusion. Direct correlation between the activity of the system of pro-inflammatory cytokines and the severity of LPO processes was
established; it must be taken into account when planning a complex of therapeutic measures.
About the Autors
Corresponding author: Elena V. Dontsova, Dr. Sci. (Med.), Professor of the Department of Dermatovenerology and cosmetology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia; ledn89@mail.ru
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