Influence of taking a synbiotic during pregnancy on the development of atopic dermatitis in children


N.A. Kholodilova, K.N. Monakhov

Pavlov University, St. Petersburg, Russia
Background. Atopic dermatitis (AD) is one of the most common dermatological diseases. Over the past decades, there has been a significant increase in the incidence and an increase in the proportion of severe dermatosis. AD worsens during pregnancy. There is a high risk of manifestations of AD in a child in the first year of life.
Objective. Evaluation of the effectiveness of the use of the synbiotic by pregnant women as a prophylaxis of AD in their children. Methods. A comparative analysis of the anamnesis data and clinical manifestations in 60 women with AD at various gestational ages, as well as an analysis of the state of their children at the present time was carried out. In group I (25 patients), the synbiotic preparation was administered orally during meals, 1–2 sachets per day for 1–3 months. Group II (35 patients) was used as a control.
Results. In group I, AD in children developed in 16% of cases; in group II – in 57.15%. Food intolerance as a predictor of the development of AD in children in group II was observed in 65.7% of cases, in group I – in 28%.
Conclusion. The use of a synbiotic drug during pregnancy by patients with AD reduces the likelihood of developing this disease and the risk of developing food intolerance in their children.

About the Autors

Corresponding author: Natalya A. Kholodilova, Associate Professor at the Department of Dermatovenereology with Clinic, Pavlov University, St. Petersburg, Russia;

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