Neuroimmune interactions in the pathogenesis of atopic dermatitis: current state of the problem


DOI: https://dx.doi.org/10.18565/pharmateca.2021.8.27-33

E.A. Orlova, Yu.A. Kandrashkina, E.M. Kostina

Penza Institute for Advanced Medical Education – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia
A review of the current generalizing data of the neuroimmunological concept of the pathogenesis of atopic dermatitis (AD) is presented. It touches on the aspects of psychoneuroimmunology and stress associated with this pathology, the role of neuropeptides in the development of inflammatory skin reaction. The review reveals the psychosomatic aspects of the pathogenesis of AD, presents the substantiation of the role of neuroimmune factors in the mechanism of its development. Analysis of the literature indicates the need for a comprehensive assessment of the pathogenetic mechanisms of the development of this disease, taking into account the role of neurotransmitters in the development of an inflammatory skin reaction, their relationship with the immune system and their contribution to the development of the main symptoms of dermatosis. The relevance of studying the topic is attributable to the increase in the prevalence of this patho-logy and often the ineffectiveness of traditional anti-inflammatory therapy. Most researchers consider the current situation as a result of underestimation of stressogenic and neuroimmune factors in the pathogenesis of AD. The search and application of antagonists of neurotransmitters or their receptors will open up new perspectives in the treatment of AD due to an important role of neurogenic inflammation in the mechanism of its development. Further research in this direction is relevant and significant.

About the Autors


Corresponding author: Ekaterina A. Orlova, Dr. Sci. (Med.), Professor at the Department of Allergology and Immunology, Penza Institute for Advanced Medical Education – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; tel. +7 (8412) 53-45-92; lisaorl@yandex.ru
Address: 8A Stasova St., Penza 440060, Russian Federation


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