The variety of effects of ambroxol in the treatment of acute respiratory infections in children


DOI: https://dx.doi.org/10.18565/pharmateca.2022.1.79-84

N.A. Geppe, M.D. Shakhnazarova, S.I. Shatalina, I.M. Farber, O.G. Sukhovyeva, M.I. Mitkina

Department of Children’s Diseases, N.F. Filatov Clinical Institute of Children’s Health, Sechenov University, Moscow, Russia
The article discusses the main, as well as little-studied effects of ambroxol, a mucoactive drug widely used as a mucokinetic and mucolytic. Modern data on pharmacokinetics, pathogenetic mechanisms of action, efficacy and safety of ambroxol use in children with acute respiratory diseases are presented. Long-term experience of using ambroxol indicates that it has unique properties that actively influence the basic mechanisms of coughing, physiological production and transport of bronchial secretions, and the activity of the surfactant system.

About the Autors


Corresponding author: Marina D. Shakhnazarova, Cand. Sci. (Med.), Associate Professor at the Department of Children’s Diseases, N.F. Filatov Clinical Institute of Children’s Health, Sechenov University, Moscow, Russia; marinashakh@mail.ru


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