Acne (acne vulgaris) is a chronic inflammatory disease of the pilosebaceous follicle, the characteristic manifestations of which include open and closed comedones, as well as papules, pustules, nodes. Acne is diagnosed in 9.4% of the general population and belongs to multifactorial dermatoses, accompanied by excessive production of sebum, follicular hyperkeratosis of the excretory ducts of the sebaceous glands, followed by their occlusion, hypercolonization of Cutibacterium acnes and an inflammatory reaction. The study of the pathogenesis of the disease is relevant, because allows to expand the range of drugs for treatment and affect all links of pathogenesis thoroughly and comprehensively. The literature review presents the main pathogenetic aspects of the development of acne vulgaris.

Keywords: neuropeptides, microbiome, acne, pathogenesis, inflammation