Modern concepts of microbial biofilms


DOI: https://dx.doi.org/10.18565/pharmateca.2020.6.34-42

A.A. Khryanin (1), G.Yu. Knorring (2)

1) Novosibirsk State Medical University, Novosibirsk, Russia; 2) A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
A review of current ideas about the microbial biofilms is presented. Stages of development, structure and components of biofilms as possible factors of antibiotic resistance are discussed. Examples of various types of antibiotic resistance in biofilm bacteria are provided. The process of collective regulation through coordination of gene expression in a bacterial population that mediates the specific behavior of cells is considered. Particular attention is paid to the role of microbial biofilms in the development of gynecological pathology. The authors evaluate various approaches that affect the components of biofilms in order to reduce their resistance/integrity using a combination of antibacterial drugs and enzymes of various origins. Methods of influence on matrix components, signaling molecules, and adhesion factors are recognized as promising. A model of the effect on biofilms using hyaluronidase is presented.

About the Autors


Corresponding author: Aleksey A. Khryanin, Dr. Sci. (Med.), Professor at the Department of Dermatovenerology and Cosmetology, Novosibirsk State Medical University; Vice President of the Association of Obstetricians-Gynecologists and Dermatovenerologists, Novosibirsk, Russia; e-mail: khryanin@mail.ru
Address: 52, Krasny Prospekt, Novosibirsk 630091, Russian Federation


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