Drug-induced nightmares


DOI: https://dx.doi.org/10.18565/pharmateca.2019.9.35-46

T.M. Ostroumova (1), O.D. Ostroumova (1, 2), A.I. Kochetkov (2), A.P. Pereverzev (2)

1) Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 2) Pirogov Russian National Research Medical University, Russian Gerontological Research and Clinical Center, Moscow, Russia

According to modern concepts, nightmares are classified as parasomnias. The use of various drugs is one of the important factors inducing their appearance; in this case nightmares are called drug-induced nightmares. The incidence of drug-induced nightmares has not been precisely established, but it can reach 59% against the background of use of certain drugs (for example, mefloquine). The mechanism of development of drug-induced nightmares is most often related to their effect on various receptors and neurotransmitter systems: adrenergic, dopaminergic and cholinergic. Among the different classes of drugs, antidepressants, antiparkinsonian drugs, analgesics, drugs used to treat cardiovascular diseases and some others are more often associated with the development of nightmares. The tactics of managing patients with drug-induced nightmares involves identifying and canceling a drug that induced a nightmare or reducing its dosage, as well as prescribing this drug in the morning if possible. Prevention of drug-induced nightmares is based on the adherence to the principles of rational pharmacotherapy, especially on the avoidance of exceeding the allowable dosage of drugs.


For citations: Ostroumova T.M., Ostroumova O.D., Kochetkov A.I., Pereverzev A.P. Drug-induced nightmares. Farmateka. 2019;26(9):35–46. (in Russian). DOI: https://dx.doi.org/10.18565/pharmateca.2019.9.35-46 


About the Autors


Corresponding author: Olga D. Ostroumova, MD, Professor at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University); Head of the Laboratory of Clinical Pharmacology and Pharmacotherapy, Pirogov Russian National Research Medical University, Russian Gerontological Research and Clinical Center, Moscow, Russia; e-mail: ostroumova.olga@mail.ru
Address: 8, build. 2, Trubetskaya Street, Moscow 119991, Russian Federation


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