THE IMPORTANCE OF THE REFLUXATE NATURE FOR THE MANIFESTATION OF CLINICAL AND ENDOSCOPIC SYMPTOMS OF GASTROESOPHAGEAL REFLUX DISEASE


DOI: https://dx.doi.org/10.18565/pharmateca.2018.s3.17-20

Z.M. Orziev, D.Kh. Yuldasheva

Bukhara State Medical Institute, Bukhara, Uzbekistan
Objective: to evaluate the possible association of the refluxate nature (RN) with the features of the leading clinical endoscopic signs of GERD. Methods. In order to support objectives, 74 patients with GERD were examined, 40 (54%) men and 34 (46%) women aged
18 to 57 years (mean age, 34±4.2 years). The diagnosis of GERD was verified based on the clinical and anamnestic, radiologic and
endoscopic data using the GERD classification. Results. In cases of alkaline reflux, odynophagia, dysphagia and bitterness in the mouth were more pronounced; and with acid reflux, the significance of heartburn and eructation has increased significantly. Erosive esophagitis was more typical for acid reflux, and non-erosive esophagitis – for alkaline reflux. Conclusion. Based on the results of study, it can be concluded that RN makes a certain impact on the features of the manifestation of clinical and endoscopic signs of GERD.

About the Autors


Corresponding author: Z.M. Orziev – MD, Prof. at the Department of Propaedeutics of Internal Diseases and Clinical Pharmacology, Bukhara State Medical Institute, Bukhara, Uzbekistan; e-mail: orzavman@mail.ru


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