PD-L1 EXPRESSION IN BLADDER CANCER AGAINST THE BACKGROUND OF CHRONIC HERPESVIRUS INFECTION: RESULTS OF A PILOT STUDY


DOI: https://dx.doi.org/10.18565/pharmateca.2018.6.98-103

I.V. Kosova (1, 2), O.B. Loran (1), L.A. Sinyakova (1), L.V. Gundorova (3), V.A. Kosov (4), I.E. Pogodina (5), D.N. Kolbasov (2)

1 Department of Urology and Surgical Andrology RMACPE, Moscow, Russia; 2 Urological Department CCH n.a. V.P. Demikhov of MHD, Moscow, Russia; 3 Pathoanatomical Department CCH n.a V.P. Demikhov of MHD, Moscow, Russia; 4 Komi Republican Oncologic Dispensary, Syktyvkar, Russia; 5 Vologda Regional Clinical Hospital № 2, Cherepovets, Russia
Background. Currently, the use of checkpoint inhibitors in the treatment of bladder cancer (BC) is one of the most promising directions. PD-L1 expression in patients with EBV-associated BC is associated with an unfavorable prognosis of the disease. Description of case series. PD-L1 expression in patients with urothelial BC and the presence of viral DNA (cytomegalovirus – CMV, Epstein-Barr virus – EBV, high-risk human papillomavirus – HPV) in tumor tissue was determined in the study. PD-L1 expression of in tumor cells in patients with the presence of viral DNA in tumor tissue >60% was detected in 3 of 8 patients, in immune cells >1% occurred in 9 of 10 patients. Conclusion. Thus, in patients with BC, including non-muscle invasive BC, and with the signs of latent viral infection, especially combined (EBV+CMV+HPV), it is reasonable to determine the PD-L1 expression as a marker of unfavorable course of the tumor process. In this category of patients, treatment with anti-PD-L1 agents is possible in order to increase the disease-free period and cancer-specific survival. However, further research is required.

About the Autors


Corresponding author: I.V. Kosova – PhD, Urologist, Teaching Assistant at the Department of Urology and Surgical Andrology RMACPE, Urological Department of CCH n.a. V.P. Demikhov of the MHD, Moscow, Russia; e-mail: kosovainga@mail.ru


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