ANALYSIS OF THE EFFICACY OF THE MINI-COMBINED TEST FOR THE PREDICTION OF MODERATE LATE-ONSET PREECLAMPSIA


DOI: https://dx.doi.org/10.18565/pharmateca.2018.6.23-28

S.O. Dubrovina, Yu.S. Mutsalkhanova, V.V. Vasilyeva

Rostov State Medical University, Rostov-on-Don, Russia
Background. Despite a significant number of studies, the predictors of preeclampsia (PE), especially the more frequently occurring late-onset PE, remain understudied, which limits the ability to predict and treat this threatening complication of pregnancy.
Objective. Analysis of the efficacy of the mini-combined test for the Prediction of moderate late-onset PE. Methods. Based on a retrospective analysis of the clinical data of 645 pregnant women, two groups were formed: pregnant women with moderate late-onset PE and patients without PE. Clinical and anamnestic parameters (age, body mass index, mean blood pressure) and biochemical marker – pregnancy-associated plasma protein A – were assessed. Results. Prognostic significance of clinical maternal factors determining the prognosis of PE – age, mean blood pressure, and body mass index – was confirmed. The predictive efficacy of the mini-combined test was 44%, with 10% false-positive results. Conclusion. The low prognostic significance of the mini-combined test for late-onset PE is shown. It is concluded that for a timely early prediction of moderate late-onset PE, a search for new markers is necessary.

About the Autors


Corresponding author: S.O. Dubrovina – MD, Prof., Chief Researcher at the Rostov State Medical University, Rostov-on-Don, Russia; e-mail: s.dubrovina@gmail.com, ORCID: https://orcid.org/0000-0003-2424-2672


Similar Articles


Бионика Медиа