HELICOBACTER PYLORI-NEGATIVE PEPTIC ULCER DISEASE: HISTORICAL FACTS AND MODERN REALITIES


I.A. Oganezova, E.B. Avalueva

FSBEI HE NWSMU n.a. I.I. Mechnikov of RMH, St. Petersburg
An increase in the proportion of Helicobacter pylori-negative ulcers is confirmed by numerous studies throughout the world. The course of H. pylori-negative peptic ulcer is associated with a higher cumulative frequency of relapses and complications, long periods of healing of ulcers, and refractoriness to ongoing therapy. It is unlikely that the risk factors identified for H. pylori-negative ulcers, such as genetic markers, elderly age, and psychophysiological stress, will disappear in the future. In connection with the above mentioned, there is a need for clinical studies aimed at optimizing the strategy of treatment and prevention of peptic ulcer, not associated with H. pylori infection.

About the Autors


Corresponding author: I.A. Oganezova – MD, Prof. at the Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietology FSBEI HE «North-Western State Medical University n.a. I.I. Mechnikov» of RMH, St. Petersburg; e-mail: oganezova@rambler.ru


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