AUTOIMMUNE GASTRITIS: PATHOGENESIS, MODERN APPROACHES TO DIAGNOSIS AND TREATMENT


Yu.V. Embutnieks (1), I.N. Voynovan (1), S.V. Kolbasnikov (2), D.S. Bordin (1, 2)

1) SBHCI “Moscow Clinical Scientific and Practical Center n.a. A.S. Loginov” of Moscow Healthcare Department, Moscow; 2) SBEI HPE “Tver State Medical University” of RMH, Tver
Autoimmune gastritis (AIG) is a disease characterized by progressive atrophy of the mucous membrane of the body of the stomach with the development of iron deficiency or B12-deficiency (pernicious) anemia. In AIG, circulating antibodies to parietal cells and the Castle’s intrinsic factor are detected in the blood. The pathogenesis and symptoms of AIG are considered, the principles of its diagnosis are presented, the relationship of AIG to other autoimmune diseases, diabetes mellitus and Helicobacter pylori infection is discussed. Pathogenetic therapy of AIG has not been developed. Symptomatic treatment depends on the clinical manifestations and results of laboratory tests. It is emphasized that the eradication of H. pylori in patients with AIG is a prerequisite for the therapy of this disease.

About the Autors


Corresponding author: Yu.V. Embutnieks – MD, Head of the Department of Pathology of the Upper Gastrointestinal Tract SBHCI MCSC n.a. A.S. Loginov of Moscow Healthcare Department, Moscow; e-mail: y.embutnieks@mknc.ru


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