CEREBROPROTECTIVE EFFECTS OF FIXED-DOSE COMBINATION OF PERINDOPRIL ARGININE/INDAPAMIDE


O.D. Ostroumova (1, 2), Т.М. Ostroumova (2), E.V. Borisova (3), V.A. Perepelov (2)

1) FSBEI HE “MSMSU n.a. A.I. Evdokimov” of RMH, Moscow
2) FSAEI HE “First Moscow State Medical University n.a. I.M. Sechenov” of RMH, Moscow
3) SBHCI CCH n.a. E.O. Mukhin of Moscow Healthcare Department, Moscow

The article presents a clinical case illustrating the improvement of cognitive functions, an increase in cerebral blood flow, a decrease in the left ventricular myocardial mass index against the background of treatment of a patient with a previously untreated uncomplicated hypertension with a fixed combination of an angiotensin-converting enzyme inhibitor perindopril arginine and a diuretic indapamide. The possibilities of antihypertensive therapy, in particular, the combination of perindopril with indapamide in the correction of cognitive impairments in arterial hypertension and their pathogenetic mechanisms are discussed.

About the Autors


Corresponding author: O.D. Ostroumova – MD, Prof. at the Department of Faculty Therapy and Occupational Diseases FSBEI HE MSMSU n.a. A.I. Evdokimov of RMH, Prof. at the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases FSAEI HE «First MSMU n.a. I.M. Sechenov» of RMH; Moscow; e-mail: ostroumova.olga@mail.ru


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