APPROACHES TO THE COMBINED TREATMENT OF ACUTE MAXILLARY SYNCUSITIS ASSOCIATED WITH CHLAMIDIAL INFECTION IN CHILDREN


A.N. Markina, T.A. Kapustina, E.V. Belova, O.V. Parilova

FSC KSC SB RAS, KSC SB RAS “Scientific Research Institute of Medical Problems of the North” (SRI MPN), Krasnoyarsk
A complex examination of 58 children with acute sinusitis, hospitalized in the ENT department, was carried out. Verification of chlamydial structures was performed by polymerase chain reaction and direct immunofluorescence, the presence of antichlamydia antibodies was determined by enzyme immunoassay. A high frequency of detection of chlamydia in children with sinusitis (48% of cases) is shown. The features of clinical manifestations and immunopathological disorders accompanying acute sinusitis are presented. A scheme for the complex treatment of children with acute inflammation of the paranasal sinuses associated with chlamydial infection, which is based on the use of cyclic polyantibiotic therapy with macrolide drugs, is proposed. The most significant advantage of this therapy is a high degree of eradication of the chlamydia (87.5%), which allows for high-quality antichlamydial treatment, prevents chronic inflammation and dissemination of infection, and and helps to reduce the number of complications. High operational characteristics of the scheme determine the appropriateness of its use for the treatment of acute sinusitis associated with chlamydial infection in children. It is recommended for use in practical healthcare by otorhinolaryngologists.

About the Autors


Corresponding author: A.N. Markina – PhD, Senior Researcher at the Laboratory of Clinical Pathophysiology (Group of Pathology of ENT organs) FSC KSC SB RAS, KSC SB RAS SRI MPN, Krasnoyarsk; tel. 8 (391) 212-52-88; e-mail: rsimpnscn.ru


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