EFFICIENCY OF COMBINED TREATMENT OF INFERTILITY ASSOCIATED WITH ENDOMETRIOSIS


N.V. Artymuk (1), L.N. Danilova (2), V.O. Chervov (1), S.V. Rybnikov (2), O.A. Tachkova (1)

1) Kemerovo State Medical University, Kemerovo; 2) Kemerovo Regional Clinical Perinatal Center n.a. Prof. L.A. Reshetova, Kemerovo
A prospective, randomized trial to evaluate the effectiveness of combined treatment of endometriosis-associated infertility with the use of gonadotropin releasing hormone agonist (GRHA), gestagen (dienogest), and combined oral contraceptives in 100 patients was performed. It is shown that combined treatment of infertility in patients with endometriosis with the use of surgical method (coagulation and excision of foci of endometriosis) followed by the administration of GRHA or dienogest is effective for a third part of patients and does not differ depending on the variant of drug therapy. However, patients who received GRHA were 2 times more likely to have a non-developing pregnancy. The efficacy of both approaches to the treatment of endometriosis was high in both groups, but the frequency and severity of side effects were more significant in patients receiving GRHA.

About the Autors


Corresponding author: N.V. Artymuk – MD, Prof., Head of the Department of Obstetrics and Gynecology № 2 of the Kemerovo State Medical Academy, Chief Freelance Specialist of the Russian Ministry of Health in Obstetrics and Gynecology in the Siberian Federal District, President of the Kemerovo Regional Public Organization «Association of Obstetricians and Gynecologists», e-mail: artymuk@gmail.com


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