METABOLIC THERAPY FOR POSTHYSTERECTOMIC SYNDROME IN PERIMENOPAUSAL WOMEN


M.R. Orazov (1), M.B. Khamoshina (1), L.V. Pokul (1), T.N. Bebneva (1), D.I. Marapov (2), S.R. Polikarpova (3)

1) FSAEI HE “Peoples’ Friendship University of Russia”, Moscow; 2) FSBEI HE “Kazan State Medical University” of RMH, Kazan; 3) Russian Society of Specialists in Organic, Tissue and Placental Therapy, Moscow
The article is devoted to the actual problem of modern medicine – prevention and treatment of posthysterectomic syndrome (PHES). The study was aimed to the evaluation of the oxidative stress markers and the mental status of women with PHES on the background of treatment with human placenta hydrolyzate (HPH). The study included 62 perimenopausal women (age, 46.3±0.56 years) 3 weeks to 3 months after hysterectomy without adnexectomy (group I, n=30) and with unilateral adnexectomy (group II, n=32) not receiving menopausal hormone therapy. Severity of PHES was determined using a modified menopausal index, mental status was assessed by Beck psychometric scale, the severity of anxiety disorders – using Spielberger scale, and the level of oxidative stress markers (superoxide dismutase, glutathione peroxidase) – by enzyme immunoassay. Patients were treated with HPH for subcutaneous use (Melsmon, Japan) according to the scheme. It was found that PHES after hysterectomy is occurred in women with severe asthenia, chronic fatigue and mental distress against the background of a dysregulation of the antioxidant functions. Metabolic correction with HPH allowed to reduce the frequency of vegetovascular manifestations from 86.7 to 16.7% in the group I and from 84.4 to 21.9% in group II (p<0.001), relief the manifestation of depression and anxiety, normalize the oxidative stress indices. It is emphasized that early diagnosis of PHES, personali-zed therapy with metabolic correction in a timely manner can not only relief the neurovegetative symptoms, but also correct the signs of mental distress and other age-related diseases on the background of progressive
oxidative stress.

About the Autors


Corresponding author: M.R. Orazov – MD, Associate Professor at the Department of Obstetrics and Gynecology with a Course of Perinatology FSAEI HE «Peoples’ Friendship University of Russia», Moscow; e-mail: omekan@mail.ru


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