THERAPY WITH NONSTEROID ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH ACUTE NONSPECIFIC LOW BACK PAIN: DYNAMICS OF RENAL FUNCTION: RESULTS OF “PANDA” COGORT STUDY


I.A. Zolotovskaya (1), I.L. Davydkin (1), N.Yu. Borovkova (2)

(1) FSBEI HE “Samara State Medical University” of RMH, Samara (2) FSBEI HE “Nizhny Novgorod Medical State Academy” of RMH, Nizhny Novgorod
The «PANDA» trial was aimed to the evaluation of renal function in patients with acute nonspecific low back pain against the background of therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). The study included 407 patients who have received one of four NSAIDs: meloxicam (15 mg/day), etoricoxib (60 mg/day), nimesulide (200 mg/day) or celecoxib (200 mg/day) for 14 days. At five visits, blood pressure, glomerular filtration rate (GFR), and blood cystatin-C values were monitored. According to the results of the observation, there were no clinically significant changes in the level of systolic and diastolic blood pressure, GFR and cystatin-C concentrations between the onset of therapy and the completion of the study in all groups of patients, regardless of the NSAID taken. Statistically Significant differences in all indicators studied were noted in the group of patients with history of hypertension and diabetes mellitus compared to patients without these diseases.

About the Autors


Corresponding author: I.A. Zolotovskaya – PhD, Teaching Assistant at the Department of Hospital Therapy with courses of Policlinic Therapy and Transfusiology FSBEI HE «Samara State Medical University» of RMH; Samara; e-mail: zolotovskay@list.ru


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