ONCOMODULATING EFFECT OF CYTOMEGALOVIRUS IN BLADDER CANCER: MYTH OR REALITY?


O.B. Loran (1), L.A. Sinyakova (1), L.V. Gundorova (2), V.A. Kosov (3), I.V. Kosova (4), I.E. Pogodina (5), D.N. Kolbasov (4)

(1) Department of Urology and Surgical Andrology FSBEI FPE RMACPE of RMH, Moscow (2) Pathologoanatomical Department SBHCI CCH №68 of Moscow Healthcare Department, Moscow (3) Komi Republican Oncological Dispensary, Syktyvkar (4) Department of Urology SBHCI CCH №68 of Moscow Healthcare Department, Moscow (5) Vologda Regional Clinical Hospital №2, Cherepovets
The examination and treatment of 100 patients (72 men and 28 women) aged 38 to 90 years (mean age 65±10 years) admitted to the Department of Urology CCH №68 and Department of Urology KROD with diagnosed bladder cancer (BC), in most cases in an urgent order due to gross hematuria, were performed. Additionally, blood test for immunoglobulins (Ig) IgG, IgM to herpes (HSV – herpes simplex virus) types 1 and 2, cytomegalovirus (CMV), Epstein-Barr virus (EBV), urine polymerase chain reaction (PCR) to the aforementioned viruses, urethral scraping to detect high-risk oncogenic human papilloma virus (HPV) were performed. Tumor tissue and urine samples of patients were obtained for PCR diagnostics for HSV types 1 and 2, oncogenic HPV, CMV, and EBV. A statistically significant increase in the level of viral antibodies in patients with recurrent, locally advanced bladder cancer with high malignant potential was revealed. Statistically significant correlations between the presence of viral CMV and EBV DNAs in the tumor, the level of their antibo-dies, the process stage and recurrent nature of the tumor were detected. The morphological features of the BC against the background of persistent CMV herpes viral infection were described. Potentiation of action of viruses to each other was proved. Further evaluation of the significance of lymphoid infiltration and vascular component in this category of patients is required.

About the Autors


Corresponding author: I.V. Kosova – PhD, Urologist at the Department of Urology SBHCI CCH № 68 of Moscow Healthcare Department; e-mail: kosovainga@mail.ru


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