INFLUENCE OF PROBIOTICS ON THE COMPOSITION OF MICROFLORA OF THE COLON AND SERUM CYTOKINE LEVELS IN PATIENTS WITH IRRITABLE BOWEL SYNDROME


S.S. Belous, I.L. Khalif, T.K. Koreneva, E.A. Konovich

FSBI State Scientific Center of Coloproctology n.a. A.N.Ryzhih of RMPH, Moscow
The article presents the results of the study aimed to the evaluation of the characteristics of the composition of the intestinal microflora and immune status in patients with various forms of irritable bowel syndrome (IBS) during therapy with multistrain probiotic complexes. After treatment, there was an increase of levels of both pro- and anti-inflammatory cytokines. These changes may reflect the fact that the appearance of a large number of microorganisms in the intestinal lumen activates the local immune system. The clinical picture was characterized by the decrease of duration and intensity of symptoms such as abdominal pain and bloating. In this connection, it seems appropriate to recommend multistrain probiotics in combination therapy with drugs that normalize the peristaltic activity of the intestine.

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About the Autors


S.S. Belous - Gastroenterologist, Junior Researcher at the Department for the Study of Inflammatory and Functional Bowel Diseases FSBI SSCC n.a. A.N. Ryzhih of RMPH, Moscow
I.L. Khalif – Doctor of Medical Sciences, Prof., Gastroenterologist, Head of the Department for the Study of Inflammatory and Functional Bowel Diseases FSBI SSCC n.a. A.N. Ryzhih of RMPH, Moscow
T.K. Koreneva - FSBI SSCC n.a. A.N. Ryzhih of RMPH, Moscow
E.A. Konovich - FSBI SSCC n.a. A.N. Ryzhih of RMPH, Moscow


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