BONE MARROW STEM CELLS TRANSPLANTATION AS A NEW METHOD OF TREATMENT OF HEPATIC FAILURE. THE CURRENT STATE OF THE PROBLEM


M. Yu. Shagidulin (1, 2), N.A. Onishchenko (1)

(1) FSBI "Federal Research Center of Transplantation and Artificial Organs n.a. Acad. V.I. Shumakov" of RMPH, Moscow; (2) SBEI HPE First MSMU n.a. I.M. Sechenov, Moscow
The progressive increase in the number of patients with hepatic failure (HF), high morbidity, disability and mortality of these patients indicate a lack of effectiveness of the existing conservative and surgical treatment of this disease and the need for the search of new, more effective treatments. Currently, liver transplantation is the only effective method of treatment, but the ever-increasing deficit of donor organs and the increasing number of patients needing for transplants do not allow wide use of this method of treatment for all patients with HF. The use of stem cells for the treatment of liver diseases represents a new approach to the strategy of treatment of HF. This article focuses on the current state of the problem of treatment of HF using cellular technology through the use of stem/progenitor cells of the bone marrow .

About the Autors


M.Yu. Shagidulin – PhD in Medical Sciences, Head of Department of Experimental Transplantation and Artificial Organs FSBI "Federal Research Center of Transplantation and Artificial Organs n.a. Acad. V.I. Shumakov" of RMPH, Associate Professor at Department of Transplantation and Artificial Organs SBEI HPE First MSMU n.a. I.M. Sechenov; tel. 8(499) 196-87-90
Onishchenko Nina Andreevna - MD, Professor, Head of the laboratory of biotechnology of stem cells FSBI "Federal Research Center of Transplantation and Artificial Organs n.a. Acad. V.I. Shumakov" of RMPH (Director – Gotye S.V., Academician of RAMS, Professor), Moscow


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