POTENTIALS FOR THE USE OF MELATONIN IN ISCHEMIC STROKE


M.G. Poluektov, S.L. Tsenteradze

Pineal hormone melatonin influences various functions of the human body, having a chronobiological, gonadotropic, immunomodulatory and other effects. Potential for the reduction of the size of the ischemic brain injury, which is associated with its antioxidant properties, is one of the important effects of melatonin. Its neuroprotective effect has been demonstrated in animal experiments. Although the data on its use in ischemic stroke in humans are limited, it was shown, however, that melatonin and melatonin agonists may be effective in stroke-associated pathological conditions (delirium, insomnia).

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