ISSN 2073–4034
eISSN 2414–9128

Современное состояние проблемы применения антиоксидантов в фармакотерапии болезни Паркинсона

Абаимов Д.А., Зорина Е.А., Шабалина А.А., Сычев Д.А.

1) Российский центр неврологии и нейронаук, Москва, Россия; 2) Центр геномных исследований мирового уровня «Центр предиктивной генетики, фармакогенетики и персонализированной терапии» ФГБНУ РНЦХ им. акад. Б.В. Петровского, Москва, Россия; 3) Российская медицинская академия непрерывного профессионального образования, Москва, Россия

В представленном обзоре обсуждаются перспективы применения различных антиоксидантов в качестве нейропротективных препаратов при болезни Паркинсона (БП). Подробно представлены экспериментальные исследования антиоксидантов на различных лабораторных моделях паркинсонизма. Дан обзор основных клинических исследований антиоксидантов в качестве лекарственных препаратов при БП. Целью работы является ознакомление читателей с текущим состоянием фармакологических исследований антиоксидантов и с основными проблемами их применения при БП. В работе продемонстрирована перспективность сочетания антиоксидантов с традиционной терапией БП и освещены основные существующие ограничения, связанные с применением антиоксидантов в клинической практике. 

Для цитирования: Абаимов Д.А., Зорина Е.А., Шабалина А.А., Сычев Д.А. Современное состояние проблемы применения антиоксидантов в фармакотерапии болезни Паркинсона. Фарматека. 2026;33(6):22-33. DOI: https://dx.doi.org/10.18565/pharmateca.2026.6.22-33

Вклад авторов: Авторы внесли равный вклад на всех этапах работы и подготовки статьи.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Финансирование: Работа выполнена без спонсорской поддержки.

Ключевые слова

антиоксиданты
болезнь Паркинсона
окислительный стресс
активные формы кислорода

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Об авторах / Для корреспонденции

Абаимов Денис Александрович, к.б.н., старший науч. сотр., руководитель группы фармакокинетики Отдела лабораторной диагностики Института клинической и профилактической неврологии, Российский центр неврологии и нейронаук, Москва, Россия; abaimov@neurology.ru,
ORCID: https://orcid.org/0000-0001-6888-3223, eLibrary SPIN: 7548-0933, Scopus Author ID: 22133763300 (автор, ответственный за переписку)
Зорина Екатерина Андреевна, младший науч. сотр. группы фармакокинетики Отдела лабораторной диагностики Института клинической и профилактической неврологии, Российский центр неврологии и нейронаук, Москва, Россия; katuzorina@mail.ru,
ORCID: https://orcid.org/0009-0000-9575-9308, eLibrary SPIN: 4303-0262, Scopus Author ID: 58181026900
Шабалина Алла Анатольевна, д.м.н., ведущий науч. сотр., руководитель Отдела лабораторной диагностики Института клинической и профилактической неврологии, Российский центр неврологии и нейронаук, Москва, Россия; shabalina@neurology.ru,
ORCID: https://orcid.org/0000-0001-9604-7775, eLibrary SPIN: 9414-9068, Scopus Author ID: 26664964100
Сычев Дмитрий Алексеевич, д.м.н., профессор, профессор РАН, академик РАН, заслуженный деятель науки, научный руководитель Центра геномных исследований мирового уровня «Центр предиктивной генетики, фармакогенетики и персонализированной терапии» ФГБНУ РНЦХ им. акад. Б.В. Петровского, зав. кафедрой клинической фармакологии и терапии им. академика Б.Е. Вотчала, Российская медицинская академия непрерывного профессионального образования, Москва, Россия; dmitry.alex.sychev@gmail.ru, ORCID: https://orcid.org/0000-0002-4496-3680, eLibrary SPIN: 4525-7556, Scopus Author ID: 7801389135

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