Нейроэндокринные опухоли: общая характеристика и особенности тактики ведения


А.Е. Кузьминов, В.А. Горбунова

Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина, Москва, Россия
Нейроэндокринные опухоли (НЭО) – группа редких опухолей, которые могут развиваться в любых органах, имеют свои уникальные особенности происхождения, течения и диагностики. Развитие визуальных, иммуногистохимических методов диагностики, идентификация основных биохимических маркеров способствовали увеличению выявляемости НЭО в мире. Выбор метода лечения зависит от локализации, распространенности процесса и функционального статуса опухоли.

Литература


1. Modlin I.M., Champaneria M.C., Chan A.K.C., Kidd M. A three-decade analysis of 3,911 small intestinal neuroen-docrine tumors: the rapid pace of no progress. Am. J. Gastroenterol. 2007;102(7):1464–73.

2. Strosberg J.R., Nasir A., Hodul P., Kvols L. Biology and treatment of metastatic gastrointestinal neuroendocrine tumors. Gastrointest Cancer Res. 2008;2(3):113–25.

3. Berge T., Linell F. Carcinoid tumours. Fre-quency in a defined population during a 12-year period. Acta Pathol Microbiol Scand. 1976;84(4):322–30.

4. Kaltsas G.A., Besser G.M., Grossman A.B. The Diagnosis and Medical Management of Advanced Neuroendocrine Tumors. Endocrin. Rev. 2004;25(3):458511.

5. Sorbye H., Welin S., Langer S.W., et al. Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study. Ann. Oncol, 2013;24(1):152–60.

6. Garcia‐Carbonero R., Capdevila J., Crespo-Herrero G., et al. Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP‐NETs): results from the National Cancer Registry of Spain (RGETNE). Ann. Oncol, 2010;21(9):1794–803.

7. Sorbye H., Strosberg J., Baudin E., et al. Gastroenteropancreatic high‐grade neuroendocrine carcinoma. Cancer. 2014;120(18):2814–23. Doi:10.1002/cncr.28721.

8. Rindi G., Falconi M., Klersy C., et al. TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J. Natl. Cancer Inst. 2012;104(10):764–77.

9. Korse C.M., Taal B.G., Vincent A., et al. Choice of tumour markers in patients with neuroendocrine tumours is dependent on the histological grade. A marker study of Chromogranin A, Neuron specific enolase, Progastrin‐releasing peptide and cytokeratin fragments. Eur. J. Cancer. 2012;48(5):662–71. Doi: 10.1016/j.ejca.2011.08.012.

10. Baudin E., Gigliotti A., Ducreux M., et al. Neuron‐specific enolase and chromogranin A as markers of neuroendocrine tumours. Br. J. Cancer., 1998;78(8):1102.

11. Brenner B., et al. Small cell carcinomas of the gastrointestinal tract: clinicopathological features and treatment approach. Semin Oncol. 2007;34(1):43–50. Doi: 10.1053/j.seminoncol.2006.10.022

12. Sørbye H., Westre B., Horn A. Curative surgery after neoadjuvant chemotherapy in metastatic poorly differentiated neuroendocrine carcinoma. Eur. J. Surg. Oncol. (EJSO). 2007;33(10):1209–10.

13. Yamaguchi T., Machida N., Morizane C., et al. Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system. Cancer Sci. 2014;105(9):1176–81. Doi: 10.1111/cas.12473.

14. Moertel C.G., Kvols L.K., O’Connell M.J., Rubin J.Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin. Evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer. 1991;68(2):227–32.

15. Mitry E., Baudin E., Ducreux M., et al. Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin. Br. J. Cancer. 1999;81(8):1351. Doi: 10.1038/sj.bjc.6690325

16. Iwasa S., Morizane C., Okusaka T., et al. Cisplatin and etoposide as first‐line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas. Jap. J. Clin. Oncol. 2010;40(4):313–18. Doi: 10.1093/jjco/hyp173.

17. Deutschbein T., Unger N., Yuece A., et al. Chemotherapy in patients with progressive, undifferentiated neuroendocrine tumors: a single‐center experience. Hormone and metabolic research Hormon‐und Stoffwechselforschung. Hormon. Metabol. 2011;43(12):838–43. Doi: 10.1055/s-0031-1284354.

18. Patta A. Fakih M. First‐line cisplatin plus etoposide in high‐grade metastatic neuroendocrine tumors of colon and rectum (MCRC NET): review of 8 cases. Anticancer Res. 2011;31(3):975–78.

19. Munhoz R.R., et al. Combination of irinotecan and a platinum agent for poorly differentiated neuroendocrine carcinomas. Rare tumors. 2013;5(3):e39–e39. DOI: 10.4081/rt.2013.e39.

20. Okita N.T., Kato K., Takahari D., et al. Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly‐differentiated neuroendocrine carcinoma. Gastric. Cancer. 2011;14(2):161–65.

21. Nakano K., Takahashi S., Yuasa T., et al. Feasibility and efficacy of combined cisplatin and irinotecan chemotherapy for poorly differentiated neuroendocrine carcinomas. Jap. J. Clin. Oncol. 2012;42(8):697–703.

22. Okuma H.S., et al. Irinotecan plus Cisplatin in Patients with Extensive‐Disease Poorly Differentiated Neuroendocrine Carcinoma of the Esophagus. Anticancer Res. 2014;34(9):5037–41.

23. Lu Z., Li J., Lu M., et al. Feasibility and efficacy of combined cisplatin plus irinotecan chemotherapy for gastroenteropancreatic neuroendocrine carcinomas. Med. Oncol. 2013;30(3):1–5.

24. Kulke M.H., Stuart K., Enzinger P.C., et al. A phase II trial of irinotecan and cisplatin in patients with metastatic neuroendocrine tumors. Digest. Dis. Sci. 2006;51(6):1033–38.

25. Welin S., Sorbye H., Sebjornsen S., et al. Clinical effect of temozolomide‐based chemotherapy in poorly differentiated endocrine carcinoma after progression on first‐line chemotherapy. Cancer. 2011;117(20):4617–22. Doi: 10.1002/cncr.26124.

26. Ezziddin S., Opitz M., Attassi M., et al. Impact of the Ki‐67 proliferation index on response to peptide receptor radionuclide therapy. Eur. J. Nucl. Med. Mol. Imag. 2011;38(3):459–66.


Об авторах / Для корреспонденции


Автор для связи: А.Е. Кузьминов, к.м.н., науч. сотрудник, НМИЦ им. Н.Н. Блохина, Москва, Россия; e-mail: alexkouzminov@mail.ru
Адрес: 115478, Россия, Москва, Каширское шоссе, 24


Похожие статьи


Бионика Медиа