Evaluation of efficacy of the thiazide diuretic hydrochlorothiazide in mono- and combined therapy in patients with arterial hypertension distributed according to blood rennin-aldosterone profile
We conducted the evaluation of efficacy and the role of the thiazide diuretic hydrochlorothiazide in mono- and combined therapy in patients with arterial hypertension distributed according to blood renin-aldosterone profile. The study included 340 patients with essential hypertension. The plasma renin activity (PRA, range 1,0-3,0 ng/ml/h) and aldosterone plasma levels (range 0,18-0,83 nmol/l or 5-23 ng/ml/h) were evaluated by radioimmunoassay method. Normal range of ratio aldosterone plasma levels to PRA is 5-23. The conclusion of the study is that it possible to give the patients with PRA 0,22-1,0 ng/ml/h and ratio aldosterone plasma levels to PRA 5-50 hydrochlorothiazide in metabolic neutral dose (less then 12,5 mg/day) in monotherapy or in combination with enalapril or losartan in low doses with the titration to achieve blood pressure levels.

Keywords: losartan, renin, enalapril, aldosterone, hypertension, hydrochlorothiazide, atenolol