The role of intestinal microbiota in the development of atopic dermatitis


DOI: https://dx.doi.org/10.18565/pharmateca.2025.7.76-82

Sysoeva A.S., Orlova E.A., Levashova O.A., Kulieva O.A., Kandrashkina Yu.A.

1) Penza Institute for Advanced Medical Training – Branch of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; 2) Penza State University, Penza, Russia
Intestinal microbiota plays a significant role in the development of the immune system and has a protective effect in the formation of atopy. Recently, there has been a growing interest in studying the role of intestinal microbiota in the pathogenesis of atopic dermatitis (AD). The review discusses the mechanisms of influence of the intestinal microbiome on the development and course of AD. Patients with AD have intestinal dysbiosis, characterized by a deficiency of lactobacilli, bifidobacteria and excessive growth of pathogenic and opportunistic microorganisms. Prospects for correction of the intestinal microbiome for the treatment of AD are presented.
Keywords: microbiome, atopic dermatitis, intestinal microbiota, probiotics
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About the Autors

A.S. Sysoeva, Assistant, Department of Medical Microbiology and Laboratory Medicine, Penza Institute for Advanced Medical Training – branch of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; sysojchik@yandex.ru, ORCID: https://orcid.org/0009-0008-6981-464X, eLibrary SPIN: 1026-7270 (corresponding author)
E.A. Orlova, Penza Institute for Advanced Medical Training – branch of the Russian Medical Academy of Continuous Professional Education, Department of Allergology and Immunology with a Course in Dermatovenereology and Cosmetology, Penza, Russia; ORCID: https://orcid.org/0000-0002-3902-2018
O.A. Levashova, Penza Institute for Advanced Medical Training – branch of the Russian Medical Academy of Continuous Professional Education, Department of Medical Microbiology and Laboratory Medicine, Penza, Russia; ORCID: https://orcid.org/0000-0002-8440-6598
Oksana A. Kulieva, Assistant, Department of Medical Microbiology and Laboratory Medicine, Penza Institute for Advanced Medical Training – branch of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; golikowa.oksana@yandex.ru, ORCID: https://orcid.com/0009-0004-2452-747X, eLibrary SPIN: 4855-4432 (corresponding author)
Yu.A. Kandrashkina, Penza State University, Department of Obstetrics and Gynecology, Penza, Russia; ORCID: https://orcid.org/0000-0002-5537-5729


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