Generalized pustular psoriasis. literature review and clinical experience with IL-17 inhibitor therapy


DOI: https://dx.doi.org/10.18565/pharmateca.2025.5.50-55

Kokhan M.M., Keniksfest Yu.V., Filimonkova N.N., Grishaeva E.V., Stukova E.I.

Ural Research Institute of Dermatovenereology and Immunopathology, Yekaterinburg, Russia
The article presents current literature data on the clinical manifestations and course of generalized pustular psoriasis (GPP), which is one of the most severe forms of psoriasis. The publication briefly presents the main features of the immunopathogenesis of GPP, the role of proinflammatory interleukin IL-17 in the development of the psoriatic process, and also highlights approaches to treating the disease. Clinical cases of GPP therapy using monoclonal antibodies that inhibit proinflammatory IL-17A, which are the active ingredient of secukinumab, are presented. A pronounced clinical effect of treatment is shown. The described clinical cases indicate that the genetically engineered biological drug secukinumab can be the drug of choice in the treatment of patients with GPP when other treatment methods are ineffective, and its use is effective and safe.
Keywords: generalized pustular psoriasis, secukinumab, monoclonal antibodies
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About the Autors

Muza M. Kokhan, Dr. Sci. (Med.), Professor, Head of the Scientific Clinical Department of Dermatology, Ural Research Institute of Dermatovenereology and Immunopathology, Yekaterinburg, Russia; mkokhan@yandex.ru, ORCID: https://orcid.org/0000-0001-6353-6644 (corresponding author)
Yu.V. Keniksfest, Dr. Sci. (Med.), Associate Professor, Head of the Department of Chronic Dermatoses for Adults, Ural Research Institute of Dermatovenereology and Immunopathology, Yekaterinburg, Russia; keniksfest@mail.ru, ORCID: https://orcid.org/0000-0001-8431-5664
N.N. Filimonkova, Dr. Sci. (Med.), Professor, Leading Researcher, Scientific Clinical Department of Dermatology, Ural Research Institute of Dermatovenereology and Immunopathology, Yekaterinburg, Russia; nnfil2008@mail.ru, ORCID: https://orcid.org/0000-0003-2872-3836
E.V. Grishaeva, Cand. Sci. (Med.), Head of Clinic, Ural Research Institute of Dermatovenereology and Immunopathology, Yekaterinburg, Russia; egrishaeva@yandex.ru, ORCID: https://orcid.org/0000-0001-9891-1942
E.I. Stukova, Cand. Sci. (Med.), Researcher, Scientific Clinical Department of Dermatology, Ural Research Institute of Dermatovenereology and Immunopathology, Ekaterinburg, Russia; evstukova@mail.ru, ORCID: https://orcid.org/0000-0003-4580-7839


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