Immunopathogenesis of itching in Hodgkin’s lymphoma: current status


DOI: https://dx.doi.org/10.18565/pharmateca.2025.5.6-12

Popova A.I., Orlova E.A., Kostina E.M., Nikolashina O.E.

1) Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Department of Allergology and Immunology with a Course in Dermatovenereology and Cosmetology, Penza, Russia; 2) Penza State University, Department of Microbiology, Epidemiology and Infectious Diseases, Penza, Russia
Itching is a frequent and debilitating symptom of Hodgkin’s lymphoma (HL), significantly reducing the quality of life of patients. This review is devoted to current understanding of the mechanisms of itching in this disease to deepen our understanding of the pathogenesis of this symptom and search for new therapeutic strategies aimed at improving the quality of life of patients.
The role of various factors, including cytokines, histamine and neurotransmitters, in its development is analyzed. Particular attention is paid to the interaction of these mechanisms and their impact on the intensity and duration of itching. Promising research areas that contribute to a deeper understanding of the pathogenesis of this symptom and the development of new therapeutic strategies are also analyzed. The need for an interdisciplinary approach to early diagnostics of Hodgkin’s lymphoma, taking into account itching as one of the possible clinical manifestations, and the importance of timely treatment are emphasized.
Keywords: itching, neuropeptides, Hodgkin’s lymphoma, pathogenesis, cytokines, treatment
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About the Autors

Anna I. Popova, Postgraduate Student, Department of Allergology and Immunology with a Course in Dermatovenereology and Cosmetology, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; annapopova3107@gmail.com, ORCID: https://orcid.org/0009-0006-4847-1735 (corresponding author)
Ekaterina A. Orlova, Dr. Sci. (Med.), Associate Professor, Head of the Department of Allergology and Immunology with a Course in Dermatovene-reology and Cosmetology, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; lisaorl@yandex.ru, ORCID: https://orcid.org/0000-0002-3902-2018
Elena M. Kostina, Dr. Sci. (Med.), Associate Professor, Professor at the Department of Allergology and Immunology with the Course of Dermatovenereology and Cosmetology, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; elmihkostina@yandex.ru, ORCID: https://orcid.org/0000-0003-1797-8040
Olga E. Nikolashina, Cand. Sci. (Med.), Associate Professor, Department of Microbiology, Epidemiology and Infectious Diseases, Penza State University, Penza, Russia, nikolashina515@mail.ru, ORCID: https://orcid.org/0009-0001-6903-2356


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