Known and little-known facts about acetylsalicylic acid


DOI: https://dx.doi.org/10.18565/pharmateca.2025.1.57-63

O.D. Ostroumova, S.V. Litvinova, N.A. Plotnikova, A.I. Kochetkov, A.V. Arablinsky, S.S. Eremina

1) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Acetylsalicylic acid (ASA) remains one of the most widely used drugs in cardiology due to its antiplatelet properties. However, long-term use of ASA is associated with the risk of side effects, especially from the gastrointestinal tract. The choice of ASA form plays an important role in minimizing side effects. Enteric-coated forms reduce the risk of gastropathy, but often have low bioavailability and insufficient antiplatelet effect, especially in patients with concomitant obesity and diabetes mellitus. Buffered forms demonstrate better tolerability and maintain high bioavailability, which makes them preferable for long-term therapy. Also, as a preventive measure for gastrointestinal complications, it is recommended to prescribe proton pump inhibitors, especially in patients with a high risk of gastrointestinal bleeding.
Keywords: adverse drug reactions, antiplatelet therapy, acetylsalicylic acid, cardiovascular diseases
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About the Autors

Olga D. Ostroumova, Dr. Sci. (Med.), Professor, Head of the Department of Therapy and Polymorbid Pathology named after Academician M.S. Vovsi, Russian Medical Academy of Continuous Professional Education; Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; ostroumova.olga@mail.ru, ORCID:
https://orcid.org/0000-0002-0795-8225; eLibrary SPIN: 3910-6585 (corresponding author)
Svetlana V. Litvinova, Cand. Sci. (Med.), Assistant of the Department of Therapy and Polymorbid Pathology named after Academician M.S. Vovsi, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; batyukina.svetlana@yandex.ru, ORCID: https://orcid.org/0000-0003-1316-7654
Natalia А. Plotnikova, Cand. Sci. (Med.), Associate Professor of the Department of Therapy and Polymorbid Pathology named after Academician
M.S. Vovsi, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; na_tasah_90@mail.ru, ORCID: https://orcid.org/0000-0001-5454-9339
Aleksey I. Kochetkov, Cand. Sci. (Med.), Associate Professor of the Department of Therapy and Polymorbid Pathology named after Academician
M.S. Vovsi, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; ak_info@list.ru, ORCID: https://orcid.org/0000-0001-5801-3742; eLibrary SPIN: 9212-6010
Alexander V. Arablinsky, Dr. Sci. (Med.), Associate Professor, Professor of the Department of Therapy and Polymorbid Pathology named after Academician M.S. Vovsi, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; alexar-card@mail.ru, ORCID: https://orcid.org/0000-0002-2117-5016
Sofya S. Eremina, 2nd year resident of the Department of Therapy and Polymorbid Pathology named after Academician M.S. Vovsi, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; sofya.eremina@mail.ru, ORCID: https://orcid.org/0000-0001-7989-354X


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