Obesity is a common pathology associated with carbohydrate metabolism disorders and increased cardiovascular risk. Bariatric surgery is recognized as the most effective treatment for morbid obesity, leading to significant weight loss and improved glycemic control and comorbid conditions. Despite the relatively high effectiveness of bariatric surgery compared to traditional methods of treating obesity, there are cases of both ineffective weight loss and weight regain. Due to the relatively recent introduction of bariatric surgery into medical practice, prospective long-term follow-up of patients is scarce and often contradictory. Experience in the treatment of repeated weight gain after bariatric interventions is limited and is represented mainly by surgical methods for correcting previously performed modifications of the gastrointestinal tract. The purpose of this review is to systematize the available data on the conservative treatment of weight gain: features of dietary counseling, selection of a physical activity regimen, as well as experience in the use of a number of medications.

Keywords: weight regain, orlistat, bariatric surgery, glucagon-like peptide-1 receptor agonists, sibutramine