The review article discusses the main problematic issues of the epidemiology, etiology, and pathogenesis of amiodarone-induced thyrotoxicosis (AmIT). The effect of iodine on the thyroid gland (TG) is described in detail. Particular attention is paid to the pathogenetic aspects of the development of this type of thyrotoxicosis. Issues of «type specificity» of thyroid dysfunction caused by amiodarone are discussed. The complex issues of differential diagnosis of the 1st and 2nd types of AmIT are considered. The problem of identifying the so-called mixed type is discussed. Various innovative approaches to therapy including first-line agents with or without consideration for the pathogenetic AmIT type are compared. The indications for radical treatment of this type of thyrotoxicosis are specified. The issues of cancellation and re-appointment of amiodarone and the algorithm of actions in this type of thyropathies are discussed.

Keywords: thyreostatics, amiodarone-induced thyrotoxicosis, thyroid gland, glucocorticoids, amiodarone