Background. Being one of the most common childhood allergic dermatosis, atopic dermatitis (AD) is realized under the influence of environmental factors in children at risk. Environmental conditions determine both the initiation of the formation of the atopic phenotype and the course of the disease itself. Understanding the complex mechanisms of evolution of the atopic march opens up opportunities to control and manage it.
Description of the clinical case. A case of the onset of AD in a child aged 8 weeks is presented, selective phage decontamination (SPD) as a monotherapy for 16 days made it possible to completely stop the skin syndrome.
Conclusion. The use of phage therapy in the treatment of children with AD, even in the form of monotherapy, can significantly influence the course of the disease and exclude the possibility of recurrence.

Keywords: atopic march, atopic dermatitis, bacteriophages, intestinal microbiota