Systematic review and meta-analysis: predictors of psoriatic arthritis


N.O. Pereverzina, L.S. Kruglova, T.V. Korotaeva, A.M. Lila

1) Central State Medical Academy of the Administrative Department of the President of th Russian Federation, Moscow, Russia; 2) V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
Background. Psoriasis is a chronic systemic immune-inflammatory disease that affects not only the skin, but also the musculoskeletal system. According to epidemiological and clinical studies, every fourth patient with psoriasis develops psoriatic arthritis. Early diagnosis and early initiation of therapy allows to prevent the development of severe forms and disability. Identification of early predictors of pso- riatic arthritis and referral of such patients for rheumatological examination may help to solve this problem.
Methods. The existing literature was searched in the PubMed (MEDLINE), EMBASE and Google Scholar databases for 10 years up
to 02/20/2021. The search for current registered trials was carried out in the clinical trial registries of the United States (Clinicaltrials. gov), China (Chinese Clinical Trial Registry) and the WHO International clinical trial registry platform. Statistical analyzes were prepared in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) using Statistic SPSS 26.0 (US-manufactured). Meta-analysis was prepared using RevMan 5 software.
Results. We identified 342 articles published up to February 20, 2021. After further analysis, irrelevant articles were excluded. A total of 35 articles were included in the review and analysis. psoriatic arthritis predictors include enthesitis, nail lesions, uveitis, and axial lesions. In addition, there are biomarkers for psoriatic arthritis. According to meta-analysis, a statistically significant increase in the risks of devel- oping psoriatic arthritis by 1.52 times (95% CI 1.22–1.88) was noted in the presence of damage to the nail apparatus. In addition, not only the risks of developing psoriatic arthritis but also the chances of developing psoriatic arthritis increased with statistical significance by 2.76 times (95% CI: 1.94–3.92).
Conclusion. Psoriasis and psoriatic arthritis are multifactorial diseases with sharply reduced quality of life of patients, the possible development of severe forms and disability. Therefore, early diagnosis of such conditions is very important. Nail damage can be considered as predictors of psoriatic arthritis, so it is very important for dermatologists to evaluate not only smooth skin. Further research is needed to better understand this issue.

About the Autors

Corresponding author: Natalia O. Pereverzina, Central State Medical Academy of the Administrative Department of the President of the Russian Federation, Moscow, Russia;

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