Modern data on localized scleroderma and methods of its therapy


DOI: https://dx.doi.org/10.18565/pharmateca.2022.13.49-52

N.N. Filimonkova, A.R. Temirbulatova, I.D. Kuznetsov

1) Ural Research Institute of Dermatovenereology and Immunopathology, Yekaterinburg, Russia; 2) Doctor Arbitaylo, Tyumen, Russia; 3) Department of Dermatovenereology, Academician E.A. Vagner Perm State Medical University, Perm, Russia
Chronic localized scleroderma is a rare disease of the skin and subcutaneous tissue with an unknown etiology and pathogenesis, char- acterized by a variety of clinical variants. Pathological changes occur in the form of three consecutive stages of erythema or edema, induration and the formation of sclerosis and/or atrophy; however, such staging is not observed in all cases. Localized scleroderma covers a wide range of clinical variants, from solitary skin lesions with minimal discomfort to severe subtypes such as generalized or linear scleroderma. Research on development of a modern classification, clarification of the pathogenesis of the disease and effective methods of therapy is ongoing. Topical glucocorticosteroids are the first-line treatment for localized scleroderma. Ultraviolet A1 (UVA1) phototherapy is used to treat patients with advanced lesions.

About the Autors


Corresponding author: Nina N. Filimonkova, Dr. Sci. (Med.), Professor, Leading Researcher at the Scientific Clinical Department, Ural Research Institute of Dermatovenereology and Immunopathology, Yekaterinburg, Russia; nnfil2008@mail.ru


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