Hypothyroidism is one of the most common diseases of the endocrine system. The nonspecificity of symptoms of hypothyroidism often leads to delayed diagnosis of this disease. The need for screening determination of thyroid-stimulating hormone (TSH) for early detection of hypothyroidism and initiation of its therapy continues to be actively discussed. The article discusses the role of untimely diagnosed hypothyroidism as a factor aggravating the course and compensation of concomitant pathology. At the moment, the deter- mination of the TSH level is indicated for all patients with dyslipidemia, diabetes mellitus, and reproductive disorders. However, it is also advisable to screen for hypothyroidism in people over 40 years of age with metabolic syndrome and vascular risk factors, poorly controlled arterial hypertension, chronic kidney disease, and hematological diseases. Particular attention should be paid to patients with high comorbidity. Early diagnosis of hypothyroidism and timely prescription of replacement therapy can improve the course and compensation of concomitant pathology, reduce the need for its drug therapy, providing the adherence to treatment and improvement of further prognosis for the patient.

Keywords: reproductive system diseases, hematological diseases, hyperprolactinemia, hypothyroidism, cardiovascular diseases, chronic kidney disease