The role of multidisciplinary centers in the diagnosis and treatment of neuroendocrine tumors: the experience of the Russian Expert Center for the morphological diagnosis of neuroendocrine tumors of the digestive tract at the M.F. Vladimirsky Moscow Regional Research Clinical Institute (MONIKI)


L.E. Gurevich, E.V. Bondarenko, V.E. Ashevskaya, D.N. Fedorov

M.F. Vladimirsky Moscow Regional Research Clinical Institute (MONIKI), Moscow, Russia
Most neuroendocrine tumors (NETs) are slow-growing neoplasms, often occurring in people of working age or very young, who need long-term follow-up and treatment. A multidisciplinary approach is currently the optimal method for the diagnosis and management of patients with NETs. It is associated with improving the quality and timing of diagnosis, developing the most rational individual algorithm for treating patients, increasing their survival, reducing treatment costs by eliminating the use of ineffective drugs. The global medical community considers the creation of regional interdisciplinary expert centers (IDEC) to be the global trend and the “gold” standard for the provision of medical care for NETS. In April 2019, in the Russian Federation a project to create an IDEC for the treatment of NETs was launched, and 6 such centers have already been created. The experience of the work of first of them, created on the basis of the M.F. Vladimirsky Moscow Regional Research Clinical Institute (MONIKI), is presented. From September 2019 to May 2020, 56 tumors of various localization were tested there. The problems of determining the somatostatin receptor expression in NETs of various localization in terms of indications for the use of somatostatin analogues are discussed.
Keywords: neuroendocrine tumors, interdisciplinary expert centers, somatostatin receptors, somatostatin analogues

About the Autors

Corresponding author: Larisa E. Gurevich, Dr. Sci., Professor, Department of Pathology, Oncology Department, M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia; e-mail:
Address: 61/2, build. 13, Shchepkin str., Moscow 129110, Russian Federation

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