The role of peripheral blood immunological parameters as predictive markers in cancer patients: the prognostic role of the neutrophil/lymphocyte ratio


DOI: https://dx.doi.org/10.18565/pharmateca.2019.7.28-32

I.A. Baldueva (1), A.V. Novik (1, 2)

1) N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, Russia; 2) St. Petersburg State Pediatric Medical University, St. Petersburg, Russia
The neutrophil/lymphocyte ratio is a simple and informative prognostic biomarker in patients with malignant tumors. In this review, the role of neutrophils in oncological processes and the immunological basis of their interaction with lymphocytes in the development of T-lymphocyte anergy are discussed. Examples of the clinical use of this ratio as a predictive and prognostic marker, as well as its relationship with some other factors, are presented.

About the Autors


Corresponding author: Alexey V. Novik, PhD, Senior Researcher at the Department of Oncoimmunology, Physician at the Department of Chemotherapy and Innovative Technologies, N.N. Petrov National Medical Research Center of Oncology; Associate Professor at the Department of Oncology, Pediatric Oncology and Radiotherapy, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia; e-mail: anovik@list.ru, ORCID: https://orcid.org/0000-0002-2430-7409; Address: 68, Leningradskaya Street, Pesochny settlement, St. Petersburg 197758, Russian Federation


Similar Articles


Бионика Медиа